In 80 days, the innovative treatment eliminated breast cancer metastases in mice

A group of researchers at Washington Medical University in St. Lewis, USA, developed a method that eliminated breast cancer metastases in mice, a discovery with potential implications for cancer treatment in humans.

second The study, published by the scientists in the journal Cancer DiscoveryOn March 8 of this year, all mice exposed to the innovative treatment were alive and cancer-free after 80 days.

The method involves combining two existing treatments, which work in parallel, to ensure the elimination of cancer cells. The first involves reprogramming the tumor microenvironment so that it becomes more vulnerable to attacks by the immune system, something that is accomplished by blocking the p38MAKP molecule.

The second involves stimulating the activity of T lymphocytes, the immune cells that defend our bodies against threats, such as viruses or tumors, increasing their ability to recognize and fight cancer cells.

The importance of this study is clear, because breast cancer, from the moment it spreads to other parts of the body, such as the bones, becomes very resistant to any treatment. According to Sheila A. Stewart, lead author of the study, writes, “About 70 percent of patients with metastatic breast cancer have tumors that have spread to the bones.”

Together, the two strategies could “target these bone metastases in a way that eliminates the tumor, prevents cancer recurrence and protects against bone loss,” the researcher suggested in An article published by the University of Washington Medical Center in St. Louis.

The researchers also note that the immune systems of the tested mice appear to develop long-term memory, and know exactly how to attack cancer cells if they return. “It appears that the mice were essentially vaccinated against cancer,” said Sheila Stewart.

Text by Jose Nieves Edited by Christina Pompeo