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Innovation causes tumors to self-destruct thanks to a 'Trojan horse'

Innovation causes tumors to self-destruct thanks to a ‘Trojan horse’

Plückthun Lab

A team of researchers at the University of Zurich, Switzerland, has developed a new technology that allows the body to produce therapeutic agents exactly where they need them.

Innovation can be effective in reducing the side effects of cancer treatment and in administering new treatments against Covid-19 directly in the lungs, writes the portal Express Medical.

The researchers changed A. glandular Act like one ‘Trojans’ To deliver genes for cancer treatment directly to cancer cells. This technique It does not harm healthy cellsWhich is a benefit compared to, for example, chemotherapy.

Once they reach cancer cells, genes It works to eliminate tumors. The results of the study were Published In the scientific journal PNAS.

“We tricked the tumor into eradicating it by producing anti-cancer agents from its cells,” said Sheena Smith, a co-author of the study.

Team leader Andreas Blockthon, team leader, explained that “therapeutic agents, such as therapeutic antibodies or signaling substances, usually remain in their desired place in the body, rather than spreading into the bloodstream, where they can damage healthy organs and tissues.”

Technology Homeless – As the authors call it – causing the tumor itself to produce a breast cancer antibody, called trastuzumab, in a mouse.

After a few days, the technique produced more antibodies in the tumor than when it was injected directly. The side effects observed were significantly less as well.

The researchers assert that this technique will not only be useful in treating cancer: it is also applicable to cancer Managing a wide range of biopharmaceuticals.

“By providing patients with SHREAD therapy through inhaled aerosols, our approach can allow the targeted production of antibody therapies to the virus in lung cells, where they are most needed,” Smith said.

Adenovirus vectors are already being used It is used in many vaccines Against Covid-19, Including Janssen, AstraZeneca, and Sputnik V.

Daniel Costa Daniel Costa, ZAP //

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